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Merck
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文件

C1484

Sigma-Aldrich

7-二乙氨基-3-（4-马来酰亚胺苯基）-4-甲基香豆素

≥95% purity (HPLC), solid

别名:

1 H -吡咯-2,5-二酮，1-（4-（7-（二乙氨基）-4-甲基-2-氧代-2 H -1-苯并吡喃-3-基）苯基）-, CPM

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About This Item

经验公式（希尔记法）:
C24H22N2O4
CAS号:
76877-33-3
分子量:
402.44
MDL號碼:
MFCD00077334
分類程式碼代碼:
12171500
PubChem物質ID:
24892413
NACRES:
NA.47

product name

7-二乙氨基-3-（4-马来酰亚胺苯基）-4-甲基香豆素, ≥95% (HPLC), solid

品質等級

100

化驗

≥95% (HPLC)

形狀

solid

顏色

yellow

溶解度

DMSO: soluble
methanol: soluble

應用

diagnostic assay manufacturing
hematology
histology

儲存溫度

−20°C

SMILES 字串

CCN(CC)c1ccc2C(C)=C(C(=O)Oc2c1)c3ccc(cc3)N4C(=O)C=CC4=O

InChI

1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3

InChI 密鑰

YGIABALXNBVHBX-UHFFFAOYSA-N

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相关类别

一般說明

7-二乙氨基-3-（4-马来酸亚胺基苯基）-4-甲基香豆素（CPM）是具有高度荧光特性，含巯基（-SH）的香豆素衍生物。激发和发射波长分别为355 nm和460 nm。

應用

7-二乙氨基-3-（4-马来酸亚胺基苯基）-4-甲基香豆素用于：
  • 作为无毒替代品，与抗体结合（93）
  • 在人 N--肉豆蔻酰基转移酶测定中，辅助荧光检测辅酶A（CoA-SH）（94）
  • 重组蛋白热稳定性转变测定（95）

生化／生理作用

用于监测硫醇的释放，定量微孔板反应中的硫醇，并通过核仁蛋白染色区分增殖的癌细胞。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
MKCW8175
MKCV5953
MKCV1087
MKCR2045
MKCR7205

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Targeting Acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases
Cao JS, et al.
The Journal of biological chemistry, 286(48), 41838-41851 (2011)
F C Ayers et al.
Analytical biochemistry, 154(1), 186-193 (1986-04-01)
A microfluorometric assay for thiols has been developed using the thiol-specific fluorochrome N-[4-(7-diethylamino-4-methyl-3-coumarinyl)phenyl]maleimide (CPM). The technique may be used to quantitate either cellular or plasma thiols over a range of 0.01 to 3.0 nmol and may be used with as
Victor Goncalves et al.
Analytical biochemistry, 421(1), 342-344 (2011-11-05)
N-myristoylation is the irreversible attachment of a C(14) fatty acid, myristic acid, to the N-terminal glycine of a protein via formation of an amide bond. This modification is catalyzed by myristoyl-coenzyme A (CoA):protein N-myristoyltransferase (NMT), an enzyme ubiquitous in eukaryotes
W Feng et al.
Molecular pharmacology, 55(5), 821-831 (1999-04-30)
Quinones undergo redox cycling and/or arylation reactions with key biomolecules involved with cellular Ca2+ regulation. The present study utilizes nanomolar quantities of the fluorogenic maleimide 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin (CPM) to measure the reactivity of hyperreactive sulfhydryl moieties on sarcoplasmic reticulum (SR) membranes
D J Steenkamp
The Biochemical journal, 292 ( Pt 1), 295-301 (1993-05-15)
Methods for the qualitative and quantitative analysis of thiols by means of the fluorogenic reagent 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin are described, with particular reference to the trypanosomatid metabolites glutathionylspermidine (GSH-spermidine) and trypanothione. Second-order rate constants for the derivatization of seven different thiols under
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