C0225000

骨化三醇

European Pharmacopoeia (EP) Reference Standard

• 别名: 1α,25-二羟基维生素D₃, 1α,25-二羟胆钙化醇, 骨化三醇
• 经验公式（希尔记法）: C₂₇H₄₄O₃
• CAS号: 32222-06-3
• 分子量: 416.64
• Beilstein: 7559394
• MDL號碼: MFCD00867079
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329774770
• NACRES: NA.24

属性

• 生物源: sheep wool (grease)
• 等級: pharmaceutical primary standard
• agency: EP
• API 家族: calcitriol
• 形狀: solid
• 製造商／商標名: EDQM
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: −20°C
• SMILES 字串: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• InChI 密鑰: GMRQFYUYWCNGIN-NKMMMXOESA-N
• 基因資訊: human ... VDR(7421)

说明

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia.

Calcitriol is a biologically active metabolite of vitamin D, formed via hydroxylation of calcidiol in the kidney.

應用

Calcitriol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化／生理作用

在钙的吸收和沉积中维生素D₃的生物活性形式。 1α,25-二羟基维生素D₃对细胞分化和增殖具有广泛的作用，并可调节免疫应答和中枢神经系统功能。最近的研究表明，1α,25-二羟基维生素D₃可作为抵抗包括前列腺癌和结肠癌在内数种恶性肿瘤的化学预防剂，并显示出了与其他抗癌化合物的协同作用。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300 + H310 + H330,H372
• 防範說明: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• 危險分類: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable