67667

犬尿喹啉酸

analytical standard

• 别名: 4-羟基喹啉-2-甲酸
• 经验公式（希尔记法）: C₁₀H₇NO₃
• CAS号: 492-27-3
• 分子量: 189.17
• Beilstein: 147451
• EC號碼: 207-751-5
• MDL號碼: MFCD00006753
• 分類程式碼代碼: 41116107

属性

• 等級: analytical standard
• 化驗: ≥98.0% (HPLC)
• 儲存期限: limited shelf life, expiry date on the label
• mp: 275 °C (dec.) (lit.)
• 應用: clinical testing
• SMILES 字串: OC(=O)c1cc(O)c2ccccc2n1
• InChI: 1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
• InChI 密鑰: HCZHHEIFKROPDY-UHFFFAOYSA-N

说明

一般說明

Kynurenic acid, a tryptophan metabolite, is a naturally occurring NMDA-receptor and an α7 nicotinic acetylcholine receptor antagonist in the human brain with preferential action at both of the glycine (Gly) binding sites of the N-methyl D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors. This implies that the compound can have a physiological interaction with glutaminergic and cholinergic neurotransmission in the brain. Kynurenic acid is reported to be found in elevated levels in the cerebrospinal fluid of patients with schizophrenia. Its anticonvulsant and neuroprotective properties are experimentally reported.

應用

Kynurenic acid may be used as an analytical standard for the quantification of the analyte in serum samples, food and honeybee products using high-performance liquid chromatography with fluorescence detection.

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安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable