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Merck
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文件

51621

Supelco

可卡因标准液 盐酸盐

analytical standard

别名:

苯甲酰甲基芽子碱 盐酸盐

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About This Item

经验公式（希尔记法）:
C17H21NO4 · HCl
CAS号:
53-21-4
分子量:
339.81
EC號碼:
200-167-1
MDL號碼:
MFCD00058119
分類程式碼代碼:
41116107
PubChem物質ID:
329757722

等級

analytical standard

化驗

≥98.5% (HPLC)

儲存期限

limited shelf life, expiry date on the label

藥物控制

USDEA Schedule II; Home Office Schedule 2; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

格式

neat

儲存溫度

2-8°C

SMILES 字串

Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3

InChI

1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1

InChI 密鑰

PIQVDUKEQYOJNR-VZXSFKIWSA-N

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應用

Cocaine hydrochloride has been used as a reference standard in the detection of cocaine drug in latent fingerprints using surface assisted laser desorption ionisation time of flight mass spectrometry (SALDI-TOF-MS) or matrix assisted laser desorption ionization (MALDI-TOF-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

分别以大约 300nM、900nM 和 400nM 的 Kis 抑制多巴胺、去甲肾上腺素和 5-羟色胺转运蛋白。不同于苯异丙胺，它不会影响儿茶酚胺的释放。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

分析证书(COA)

Lot/Batch Number
BCBW6332
BCBR8262V
BCBN0999V
BCBM7358V
BCBL9017V

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Detection of drugs in lifted cyanoacrylate-developed latent fingermarks using two laser desorption/ionisation mass spectrometric methods.
Sundar L, et al.
Analyst, 139(3), 633-642 (2014)
Billy T Chen et al.
Nature, 496(7445), 359-362 (2013-04-05)
Loss of control over harmful drug seeking is one of the most intractable aspects of addiction, as human substance abusers continue to pursue drugs despite incurring significant negative consequences. Human studies have suggested that deficits in prefrontal cortical function and
Elena Martín-García et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(10), 2317-2330 (2014-03-19)
High-frequency intake and high drug-induced seeking are associated with cocaine addiction in both human and animals. However, their relationships and neurobiological underpinnings remain hypothetical. The medial prefrontal cortex (mPFC), basolateral amygdala (BLA), and nucleus accumbens (NAc) have been shown to
Emmanuelle Jordi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9511-9516 (2013-05-22)
Drugs of abuse, such as cocaine, induce changes in gene expression and epigenetic marks including alterations in histone posttranslational modifications in striatal neurons. These changes are thought to participate in physiological memory mechanisms and to be critical for long-term behavioral
Michel C Van den Oever et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(46), 18225-18233 (2013-11-15)
In addicts, associative memories related to the rewarding effects of drugs of abuse can evoke powerful craving and drug seeking urges, but effective treatment to suppress these memories is not available. Detailed insight into the neural circuitry that mediates expression
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