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About This Item
经验公式（希尔记法）:
C11H13N3O2S · HCl
CAS号:
分子量:
287.77
Beilstein:
6548866
MDL编号:
UNSPSC代码:
12352202
方案
≥97.0% (HPLC)
溶解性
methanol: 1 mg/mL, clear, colorless
SMILES字符串
Cl.NCCNS(=O)(=O)c1cccc2cnccc12
生化/生理作用
Selective casein kinase 1 inhibitor. Potent inhibitor of histamine release from human basophils when induced by phorbol ester or DiC8, but not when induced by anti-IgE, fMLP (formyl-Met-Leu-Phe) and calcium ionophore A23187. This implicates divergent pathways of basophil activation.
D O Thueson et al.
Biochemical and biophysical research communications, 144(2), 732-740 (1987-04-29)
The release of histamine and other inflammatory mediators from human basophils is triggered by numerous stimuli, including chemical, physical and receptor-mediated activators. Several mechanisms of cell activation including protein kinase C activation have been proposed to operate in these cells.
T Chijiwa et al.
The Journal of biological chemistry, 264(9), 4924-4927 (1989-03-25)
When screening various isoquinolinesulfonamide compounds which we synthesized, CKI-7, N-(2-amino-ethyl)-5-chloroisoquinoline-8-sulfonamide, was found to have a potent inhibitory action against casein kinase I and a much weaker effect on casein kinase II and other protein kinases. Kinetic analysis indicated that CKI-7
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