推荐产品
product name
CUTLL1 Human T-cell Lymphoblastic Lymphoma Cell Line,
生物源
human
包裝
vial of >1X10⁶ cells
製造商/商標名
Millipore
增長模式
N/A
技術
cell culture | mammalian: suitable
運輸包裝
dry ice
儲存溫度
≤ − 140°C
應用
T-cell acute lymphoblastic lymphoma (T-ALL) is a rare but aggressive form of non-Hodgkin lymphoma, with a high relapse rate and poor long-term survival (1). The majority of T-cell lymphoblastic leukemias and lymphomas harbors activating mutations in the NOTCH1 gene, a key signaling component required for T-cell development (2). Drugs targeting the Notch pathway are thus promising avenues for treatment of T-cell lymphoblastic leukemias. Lack of response of human T-ALL cell lines to Notch inhibitors has hampered the clinical applicability of these models.
CUTLL1 is a human T-cell lymphoblastic lymphoma cell line derived from a relapsed patient that harbors a t(7;9)(q34;q34) chromosomal translocation resulting in expression of a TCRB-NOTCH1 fusion transcript and aberrant Notch signaling (3). CUTLL1 cells demonstrate high sensitivity to gamma-secretase inhibitors, which act on the Notch pathway. CUTLL1 cells express markers of immature T-cells including CD3, CD4, CD8 and TCRαα (3).
Source:
The CUTLL1 cell line was established from pleural effusion of a relapsed 14-year-old male patient suffering from T-cell lymphoblastic lymphoma (2)
References:
1. Cancer J. 2012; 18(5): 432-8.
2. Science 2004; 306(5694): 269-71.
3. Leukemia 2006; 20(7): 1279-87.
CUTLL1 is a human T-cell lymphoblastic lymphoma cell line derived from a relapsed patient that harbors a t(7;9)(q34;q34) chromosomal translocation resulting in expression of a TCRB-NOTCH1 fusion transcript and aberrant Notch signaling (3). CUTLL1 cells demonstrate high sensitivity to gamma-secretase inhibitors, which act on the Notch pathway. CUTLL1 cells express markers of immature T-cells including CD3, CD4, CD8 and TCRαα (3).
Source:
The CUTLL1 cell line was established from pleural effusion of a relapsed 14-year-old male patient suffering from T-cell lymphoblastic lymphoma (2)
References:
1. Cancer J. 2012; 18(5): 432-8.
2. Science 2004; 306(5694): 269-71.
3. Leukemia 2006; 20(7): 1279-87.
特點和優勢
The CUTLL1 cell line is a valuable and clinically relevant model for T-cell lymphoblastic lymphoma.
儲存和穩定性
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
其他說明
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation.
免責聲明
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门