MABS165

Anti-STAM-binding protein Antibody, clone 4D12.2

clone 4D12.2, from mouse

• 别名: STAMBP, STAM-binding protein, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, AMSH
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 300
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 4D12.2, monoclonal
• 物種活性: human
• 技術: immunocytochemistry: suitable; western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_006454
• UniProt登錄號: O95630
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... STAMBP(10617)

说明

一般說明

STAM-binding protein (STAMBP) is a critical metalloprotease in ubiquitin-mediated signaling events that specifically cleaves ′Lys-63′-linked polyubiquitin chains but does not cleave ′Lys-48′-linked polyubiquitin chains. STAM-binding protein is a deubiquitinating (DUB) isopeptidase also known as AMSH, for associated molecule with the SH3 domain of STAM. STAM-binding protein plays a role in cell growth and MYC induction, potentiates BMP signaling and is key in regulating the cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. STAM-binding protein interacts with other key proteins including STAM1, SMAD6/7, SMURF2, and CHMP3. STAM-binding protein is widely expressed and can be found localized to the nucleus, cytoplasm and endosome. Defects in STAM-binding protein result in a congenital syndrome named Microcephaly-capillary malformation syndrome.

免疫原

GST-tagged recombinant protein corresponding to Human STAM-binding protein.

應用

Immunocytochemistry analysis: 1:50 dilution from a representative lot detected STAM binding protein in A431 cells
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Research Category
Signaling

Research Sub Category
Ubiquitin & Ubiquitin Metabolism

This Anti-STAM-binding protein Antibody, clone 4D12.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of STAM-binding protein.

品質

Routinely evaluated by western blotting on Jurkat cell lysate
Western Blotting Analysis: 1 µg/mL of this antibody detected STAM binding protein in 10 µg of Jurkat cell lysate

標靶描述

~50 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

法律資訊

DyLight is a registered trademark of Pierce Biotechnology, Inc.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids