推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
N275/14, monoclonal
物種活性
mouse, human, rat
技術
immunohistochemistry: suitable
western blot: suitable
同型
IgG2bκ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... SYT7(9066)
一般說明
Synaptotagmin-7 is also referred to as Synaptotagmin VII (SytVII) and is a member of the synaptotagmin family of transmembrane transporters. Synaptotagmin-7 is involved in plasma membrane repair, and possibly Ca2+-dependent exocytosis and traffiking of secretory vesicles.
特異性
This antibody recognizes the cytoplasmic C2A domain of Synaptotagmin-7. This antibody does not cross react with Synaptotagmin-6 or other Synaptotagmins (Prof. J. Trimmer, University of California, Davis.).
免疫原
Epitope: Cytoplasmic C2A domain
Recombinant protein corresponding to the cytoplasmic C2A domain of mouse Synaptotagmin-7.
應用
Anti-Synaptotagmin-7 Antibody, clone N275/14 is a highly specific mouse monoclonal antibody, that targets Synaptotagmin & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Synaptotagmin-7 in human thalamus tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
品質
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Synaptotagmin-7 in 10 µg of mouse brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Synaptotagmin-7 in 10 µg of mouse brain tissue lysate.
標靶描述
~ 45 kDa observed. Uncharacterized band(s) may appear in some lysates.
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Synaptotagmin-7 Enhances Facilitation of Cav2.1 Calcium Channels.
Djillani, et al.
eNeuro, 9 (2023)
Gaël Barthet et al.
Nature communications, 9(1), 4780-4780 (2018-11-16)
Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid precursor protein (APP), cause early-onset form of Alzheimer disease. PS and APP interact with proteins of the neurotransmitter release machinery without identified functional consequences. Here we
Christopher Weyrer et al.
Cell reports, 36(12), 109719-109719 (2021-09-23)
Synaptotagmin 7 (Syt7) is a high-affinity calcium sensor that is implicated in multiple aspects of synaptic transmission. Here, we study the influence of Syt7 on the climbing fiber (CF) to Purkinje cell (PC) synapse. We find that small facilitation and
Bassam Tawfik et al.
eLife, 10 (2021-03-23)
Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2+-sensors for vesicle fusion in mouse chromaffin cells. When
Katarina Trajkovic et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(37), 9000-9012 (2017-08-20)
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by the expansion of a CAG triplet in the gene encoding for huntingtin (Htt). The resulting mutant protein (mHtt) with extended polyglutamine (polyQ) sequence at the N terminus leads to neuronal
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