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生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
10F6.1, monoclonal
物種活性
mouse, rat, human
技術
immunohistochemistry: suitable (paraffin)
western blot: suitable
同型
IgG2aκ
NCBI登錄號
UniProt登錄號
運輸包裝
ambient
目標翻譯後修改
unmodified
基因資訊
human ... SYP(6855)
rat ... Syp(24804)
一般說明
Synaptophysin (UniProt: P07825; also known as Major synaptic vesicle protein p38) is encoded by the Syp gene (Gene ID: 24804) in rat. Synaptophysin belongs to the synaptophysin/synaptobrevin family of proteins. It is one of the major glycoproteins present in presynaptic vesicles and in various neuroendocrine cells of both neuronal and epithelial phenotype. Its structure consists of a hexameric protein of four transmembrane spans with a short cytoplasmic amino and a long carboxy-terminal tail. Both amino- and carboxy-terminals are exposed on the cytoplasmic surface of the synaptic vesicle membrane. C-terminal domain of Snaptophysin is selectively required for the endocytosis during, but not after, cessation of sustained synaptic transmission. Synaptophysin is involved in organizing membrane components may regulate endocytosis to ensure vesicle availability following sustained neuronal activity. It is also involved in the regulation of short-term and long-term synaptic plasticity. Syp / neurons display functional deficiencies and slower recovery of the recycling synaptic vesicle pool. (Ref.: Kwon, SE and Chapman, ER (2011). Neuron. 70(5): 847 854).
特異性
Clone 10F6.1 detects synaptophysin in rat, human, and mouse brain. It targets a sequence within amino acids 222-307 in rat synaptophysin.
免疫原
GST/His-tagged recombinant fragment corrsponding to 86 amino acids from the C-terminal region of rat synaptophysin.
應用
Anti-Synaptophysin Antibody, clone 10F6.1, Cat. No. MABN1193, is a highly specific monoclonal antibody that targets Synaptophysin and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Synaptophysin in human cerebellum, human cerebral cortex, and human pancreatic tissues.
Research Category
Neuroscience
Neuroscience
品質
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: A 1:50,000 dilution of this antibody detected Synaptophysin in 10 µg of rat brain tissue lysate.
Western Blotting Analysis: A 1:50,000 dilution of this antibody detected Synaptophysin in 10 µg of rat brain tissue lysate.
標靶描述
~40 kDa observed; 33.31 kDa calculated. Glycosylated form displays higher molecular weight (~38 kDa). Uncharacterized bands may be observed in some lysate(s).
聯結
Replaces: MAB368
外觀
Protein G purified
Format: Purified
Purified monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
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