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Merck
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主要文件

MAB5430

Sigma-Aldrich

Anti-Tau Antibody, Caspase Cleaved (truncated at Asp421)

clone tau-C3, Chemicon®, from mouse

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

tau-C3, monoclonal

物種活性

human

製造商/商標名

Chemicon®

技術

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

同型

IgG1

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... MAPT(4137)

特異性

Reacts with Tau, caspase cleaved (truncated at Asp421). The antibody shows no reactivity with full length tau nor other tau C-terminal truncations. The antibody stains amyloid beta treated neurons and brain tissue in Alzheimer′s disease, more specifically it stains a subset of neurofibrillary tangles, tau-containing neuritic plaques and neuropil threads.

免疫原

Epitope: Caspase Cleaved (truncated at Asp421)
Peptide corresponding to the C-terminus of tau truncated as aspartic acid 421.

應用

Anti-Tau Antibody, Caspase Cleaved (truncated at Asp421) is an antibody against Tau for use in ELISA, WB, IH.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot

Immunohistochemistry

ELISA

Optimal working dilutions must be determined by end user.

標靶描述

43 kDa (aa 1 to 421) or smaller fragments with Asp421 as the c-terminus

外觀

Format: Purified
Purified immunoglobulin. Liquid in PBS. Contains no preservative.

儲存和穩定性

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Patrice Delobel et al.
The American journal of pathology, 172(1), 123-131 (2007-12-15)
Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the assembly of tau into filaments in Alzheimer's disease and other tauopathies. Here we have investigated the time
Debra K Kumasaka et al.
International journal of physiology, pathophysiology and pharmacology, 1(1), 48-56 (2009-01-12)
A recent study demonstrated the lack of beta-amyloid (Abeta) plaque formation and accumulation of the amyloid precursor protein (APP) in a triple transgenic mouse model of Alzheimer's disease (3xTg-AD) following overexpression of the anti-apoptotic protein, Bcl-2 (Rohn et al., J.
Tau pathogenesis is promoted by A?1-42 but not A?1-40.
Hu, X; Li, X; Zhao, M; Gottesdiener, A; Luo, W; Paul, S
Mol. Neurodegener. null
John C Means et al.
Cellular and molecular neurobiology, 40(6), 911-926 (2020-01-11)
Optic nerve head astrocytes (ONHAs) are the major cell type within the optic nerve head, providing both structural and nutrient support to the optic nerve. Astrocytes are necessary for the survival of neurons with controlled activation of astrocytes being beneficial
John C Means et al.
Neurochemical research, 41(9), 2278-2288 (2016-05-26)
Mouse models of neurodegenerative diseases such as Alzheimer's disease (AD) are important for understanding how pathological signaling cascades change neural circuitry and with time interrupt cognitive function. Here, we introduce a non-genetic preclinical model for aging and show that it

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