推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
P8B1, monoclonal
物種活性
human
製造商／商標名
Chemicon®
同型
IgG2b
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... L1CAM(3897) , VCAM1(7412)
特異性
MAB2511 recognizes the human VCAM-1 molecule. The antibody inhibits VLA-4 (integrin alpha4beta1) binding and recognizes a different epitope than that which is recognized by MAB2144 (P3C4 clone).
應用
Anti-VCAM-1 Antibody, clone P8B1 detects level of VCAM-1 & has been published & validated.
Function blocking
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
外觀
Format: Purified
Purified immunoglobulin. Liquid in 0.2 M phosphate buffer to 0.25 M NaCl, pH 7.6 with 0.1% sodium azide. Caution: Sodium azide is toxic. See online MSDS.
儲存和穩定性
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.
During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Max L B Grönloh et al.
EMBO reports, 24(1), e55483-e55483 (2022-11-17)
Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration "hotspot" regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endothelial hotspots function to limit vascular leakage during transmigration events.
Thomas D Manes et al.
Arteriosclerosis, thrombosis, and vascular biology, 36(9), 1910-1918 (2016-07-23)
Circulating human T effector memory cell (TEM) recognition of nonself MHC (major histocompatibility complex) molecules on allograft endothelial cells can initiate graft rejection despite elimination of professional antigen-presenting cells necessary for naive T-cell activation. Our previous studies of CD4 TEM
Barbara Garmy-Susini et al.
The Journal of clinical investigation, 115(6), 1542-1551 (2005-05-20)
Neovascularization depends on vascular cell proliferation and on the stabilization of vessels by association of vascular smooth muscle-like pericytes with ECs. Here we show that integrin alpha4beta1 (VLA-4) and VCAM-1 promote close intercellular adhesion between ECs and pericytes and that
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