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Merck
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主要文件

FCMAB314F

Sigma-Aldrich

Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B

clone 11-5B, Milli-Mark®, from mouse

别名:

2′3′-Cyclic Nucleotide 3′-Phosphohydrolase

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
共軛:
FITC conjugate
application:
FACS
無性繁殖:
11-5B, monoclonal
物種活性:
human
citations:
技術:
flow cytometry: suitable

生物源

mouse

品質等級

共軛

FITC conjugate

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

11-5B, monoclonal

物種活性

human

製造商/商標名

Milli-Mark®

技術

flow cytometry: suitable

同型

IgG1

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... CNP(1267)

一般說明

CNPase (2′, 3′-cyclic nucleotide 3′-phosphodiesterase [or -phosphohydrolase], EC 3.1.4.37) is present in very high levels in brain and peripheral nerve. This enzyme is found almost exclusively in oligo-dendrocytes and Schwann cells, the cells that form myelin in the central and peripheral nervous system, respectively.
Immunohistochemical localization of CNPase has shown the enzyme to be restricted to oligodendrocytes and Schwann cells. The enzyme appears to be distributed in single and double loose wraps of myelin and not in compact myelin as earlier thought by most investigators. CNPase is located on the inner and outer loops of myelin, paranodally and near the inner surface of the oligodendrocyte membrane. In plaque regions of multiple sclerosis patients, the enzyme is reduced, and when CNS myelin is decreased, CNPase is one of the earlier proteins to be lost from the myelin. In addition, an enzyme that is probably identical to brain CNPase is located in the outer rod segments within the visual system, and this protein is also recognized by the monoclonal antibody 11-5B. In mixed human gliomas, the enzyme levels are reduced, although about 5% of the oligodendrocytes occasionally show normal positive staining.

特異性

Antibody recognizes Human CNPase protein.

免疫原

Purified human brain CNPase protein.

應用

Detect CNPase using this Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B validated for use in FC.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

品質

Evaluated by flow cytometry using U251 Cells.

標靶描述

48kDa Calculated

外觀

Protein A purified
Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

儲存和穩定性

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

分析報告

Control
U251 Cells

法律資訊

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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