FCMAB100P

Milli-Mark Anti-Phospho-Erk1/2 Antibody (Thr202/Tyr204, Thr185/Tyr187)-PE

clone AW39R, Milli-Mark^®, from rabbit

• 别名: Erk1 ; ; Erk2 ; ; p44-MAPK ; ; p42-MAPK ; ; MAPK2 ; ; PRKM2 ; ; p41mapk ; ; PRKM1 ; ; p44 ; ; ERK2 ; ; P42MAPK ; ; ERK ; ; p42 ; ; MAPK1 ; ; ERT1 ; ; ERT2
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: PE
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: AW39R, monoclonal
• 物種活性: mouse, rat
• 物種活性（以同源性預測）: human (based on 100% sequence homology)
• 製造商／商標名: Milli-Mark^®
• 技術: flow cytometry: suitable; western blot: suitable
• 同型: IgG
• NCBI登錄號: NP_002736.3
• UniProt登錄號: P28482
• 運輸包裝: wet ice
• 目標翻譯後修改: phosphorylation ((pThr202/pTyr204), (pThr185/pTyr187))
• 基因資訊: human ... MAPK3(5595)

说明

一般說明

Erk (Extracellular signal-Related Kinase) is a family of two, highly homologous proteins denoted as Erk1 (p44, MAPK3) and Erk2 (p42, MAPK1) that both function in the same pathway. The two proteins are often referred to collectively as Erk1/2 or p44/p42 MAP kinase. The Erk pathway is considered the classical, canonical MAPK (Mitogen-Activated Protein Kinase) signaling pathway. It is an evolutionarily conserved pathway that controls and is a critical regulator of the growth and survival through the promotion of cell proliferation and the prevention of apoptosis. Erk is involved in the control of many fundamental cellular processes including cell proliferation, survival, differentiation, apoptosis, motility and metabolism. Erk is activated by growth factor stimulation of receptor tyrosine kinases (RTKs), GPCR, and/or integrin stimulation. This activates the Ras-Raf-MEK-Erk pathway that results in the phosphorylation/activation of Erk1/2 (p44/p42) on the TxY motif (Thr202/Tyr204 and Thr185/Tyr187 for Erk1 & Erk2, respectively).

特異性

Antibody recognizes Recognizes Erk 1 & 2 only when dually phosphorylated on its TxY activation motif.

免疫原

Epitope: Phosphorylated Thr185/Phosphorylated Tyr187

Phosphorylated recombinant peptide corresponding to amino acids surrounding the pTEpY motif in the activation loop of human phospho-Erk1/2, in which the Thr and Tyr residues are phosphorylated

應用

Research Category
Signaling

Research Sub Category
MAP Kinases

This Milli-Mark Phospho-Erk1/2 antibody is validated for use in Flow & WB for the detection of the Milli-Mark Phospho-Erk1/2 protein.

品質

Evaluated by Flow Cytometry with Jurkat cells.

標靶描述

42kDa and 44kDa Observed

外觀

Protein A purified

Purified Rabbit monoclonal supernatant conjugated to phycoerythrin in buffer containing PBS with 0.05% sodium azide

儲存和穩定性

Stable for 6 months at 2-8°C from date of receipt. Protect from light.

分析報告

Control
Jurkat Cells

法律資訊

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable