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生物源
rabbit
抗體表格
serum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
rat, mouse
技術
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
mouse ... Ntn1(18208)
一般說明
Netrin-1 is a secreted, bifunctional ligand belonging to the Netrin family; a group of proteins known to act as versatile, chemotropic axon guidance cues for CNS commissural and peripheral motor axons. Netrin-1 is necessary for spinal cord oligodendrocyte development. There are two receptors with which Netrin-1 is associated and that will cause it to be either a chemoattractant or a chemorepellant for axons. Receptor Deleted in Colorectal Cancer (DCC) regulates the attraction of axons to Netrin-1, and UNC5 mediates axon repulsion from Netrin-1. Studies have shown Netrin-1 to function as a survival factor through its relationship to its receptors, inhibiting the onset of apoptosis. Netrin-1 has also been implicated in colorectal tumorigenesis via its apoptotic regulatory role. Expression of Netrin-1 has been detected in adult axons and oligodendrocytes, and is also widely observed in developing embryonic mesodermal tissues and nervous system.
特異性
Other homologies: Human (94% sequence homology).
免疫原
Epitope: Unknown
Linear peptide corresponding to mouse Netrin-1.
應用
Anti-Netrin-1 Antibody detects level of Netrin-1 & has been published & validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Growth Cones & Axon Guidance
Growth Cones & Axon Guidance
品質
Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 1:10,000 dilution of this antibody detected Netrin-1 on 10 µg of mouse brain tissue lysate.
Western Blot Analysis: 1:10,000 dilution of this antibody detected Netrin-1 on 10 µg of mouse brain tissue lysate.
標靶描述
~68 kDa observed. Characteristic proteolytic fragments of Netrin-1 found in the CNS run at lower molecular weights.
外觀
Unpurified
Rabbit polyclonal serum containing 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
分析報告
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Liqing Wang et al.
The Journal of comparative neurology, 525(13), 2915-2928 (2017-05-26)
Using Nogo antibodies with defined binding specificity, Nogo-B, but not Nogo-A, was localized on radial glia in the floor plate of mouse embryos. The presence of Nogo-B was confirmed in Nogo-A knockout mice. In explant cultures of embryonic day (E)
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