ABN473

Anti-GPR Antibody3

from rabbit, purified by affinity chromatography

• 别名: G-protein coupled receptor 3, ACCA orphan receptor
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse, human
• 技術: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProt登錄號: P46089
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... GPR3(2827)

说明

一般說明

G-protein coupled receptor 3 (GPR3) is a member of the G-protein coupled receptor 1 family that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-beta peptide (Abeta), the deposition of which is one of the pathological hallmarks of Alzheimer ′s disease (AD). GPR3 has been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.

免疫原

KLH-conjugated linear peptide corresponding to human GPR3.

應用

Detect GPR using this rabbit polyclonal antibody, Anti-GPR Antibody3 validated for use in western blotting, IHC & Immunofluorescence.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected GPR3 in human spleen tissue.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected GPR3 in human spleen cells.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

品質

Evaluated by Western Blotting in EL4 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected GPR3 in 15 µg of EL4 cell lysate.

標靶描述

~35 kDa observed.

外觀

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
EL4 cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable