ABN46

Anti-DISC1 Antibody

from rabbit, purified by affinity chromatography

• 别名: Disrupted in schizophrenia 1 protein
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 技術: western blot: suitable
• NCBI登錄號: NP_001012975.1
• UniProt登錄號: Q9NRI5
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... DISC1(27185)

说明

一般說明

Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.

免疫原

KLH-conjugated linear peptide corresponding to human DISC1 near the N-terminus.

應用

Detect Disc1 using this rabbit polyclonal antibody, Anti-DISC1 Antibody validated for use in western blotting.

品質

Evaluated by Western Blotting in human hippocampus tissue lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected DISC1 in 10 µg of human hippocampus tissue lysate.

標靶描述

~100 kDa observed. Uncharacterized band(s) may appear in some lysates.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable