ABE1082

Anti-JARID1C Antibody

from rabbit

• 别名: Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: human
• 技術: western blot: suitable
• NCBI登錄號: NP_001140174
• UniProt登錄號: P41229
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... KDM5C(8242)

说明

一般說明

JARID1C, also known as Jumonji/ARID domain-containing protein 1C, Protein SmcX, or Protein Xe169, and encoded by the gene KDM5C/DXS1272E/JARID1/SMCX/XE169, a histone demethylase that specifically demethylates ′Lys-4′ of histone H3, thereby playing a central role in histone code. JARID1C demethylates trimethylated and dimethylated but not monomethylated H3 ′Lys-4′. JARID1C does not demethylate histone H3 ′Lys-9′, H3 ′Lys-27′, H3 ′Lys-36′, H3 ′Lys-79′ or H4 ′Lys-20′. Additionally, JARID1C participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. JARID1C is localized to the nucleus. Defects in JARID1C are associated with Mental retardation, X-linked, syndromic, Claes-Jensen type (MRXSCJ) disorder. MRXSCJ patients have below average general intellectual functioning associated with impairments in adaptive behavior during development, and suffer mental retardation, progressive spastic paraplegia, seizures, and facial dysmorphism.

免疫原

Linear peptide corresponding to human JARID1C.

應用

Anti-JARID1C Antibody detects level of JARID1C & has been published & validated for use in JARID1C.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

品質

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected JARID1C in 10 µg of HEK293 cell lysate.

標靶描述

~175 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

外觀

Protein A purified

Format: Purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1