ABD122

Anti-Dishevelled Antibody

serum, from rabbit

• 别名: DSH, DVL1, DVL2, DVL3, DSH Homolog 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.75

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: serum
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: rat, mouse, human
• 技術: immunocytochemistry: suitable; western blot: suitable
• NCBI登錄號: NP_004412
• UniProt登錄號: O14640
• 運輸包裝: dry ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... DVL3(1857)

说明

一般說明

Dishevelled (DVL1), the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation. The protein acts as a transducer molecule for developmental processes, including segmentation and neuroblast specification. Dishevelled plays a role both in canonical and non-canonical Wnt signaling. DVL1 mutation is likely responsible for transformation in neuroblastomas, and the Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene, thus Dishevelled maybe important in these diseases as well.

特異性

Recognizes Human, Mouse and Rat Dishevelled 1, 2 and 3.

免疫原

GST-tagged recombinant protein corresponding to Human Dishevelled.

應用

Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in PC12 cells. (Kishida et al., 2007. Dvl regulates endo- and exocytotic processes through binding to synaptotagmin. Genes to Cells, 12, 49–61).

Research Category
Stem Cell Research

Research Sub Category
Developmental Signaling

This Anti-Dishevelled Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of Dishevelled.

品質

Evaluated by Western Blot in HEK293T cell lysate.

Western Blot Analysis: A 1:1000 of this antibody detected Dishevelled in 10 µg of HEK293T cell lysate.

標靶描述

~ 81 kDa observed

外觀

Unpurified

Rabbit polyclonal serum containing 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1