推荐产品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
human
技術
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... IRGM(345611)
一般說明
Immunity-related GTPase family M protein (IRGM), also known as Interferon-inducible protein 1 (IFI1) and LPS-stimulated RAW 264.7 macrophage protein 47 homolog (LRG-47), is a member of the interferon-inducible GTPase family. It induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. IRGM is expressed in colon, small bowel, and peripheral blood leukocytes. Mutations in IRGM have been assoicated with inflammatory bowel disease type 19 which is subdivided into Crohn′s disease and ulcerative colitis phenotypes.
特異性
This antibody recognizes the intermediate domain of IRGM.
免疫原
KLH-conjugated linear peptide corresponding to the intermediate domain of human IRGM.
應用
Detect Immunity-related GTPase family M protein using this rabbit polyclonal antibody, Anti-IRGM Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.
Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected IRGM in human brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IRGM in human brain cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IRGM in human brain cells.
品質
Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected IRGM in 15 µg of human brain tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected IRGM in 15 µg of human brain tissue lysate.
標靶描述
~31 kDa observed. Uncharacterized bands may appear in some lysates.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Hironori Bando et al.
mBio, 9(5) (2018-10-12)
Although Toxoplasma virulence mechanisms targeting gamma interferon (IFN-γ)-induced cell-autonomous antiparasitic immunity have been extensively characterized in mice, the virulence mechanisms in humans remain uncertain, partly because cell-autonomous immune responses against Toxoplasma differ markedly between mice and humans. Despite the identification
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