ABC110

Anti-ELMO1 Antibody

from rabbit, purified by affinity chromatography

• 别名: Engulfment and cell motility protein 1, Protein ced-12 homolog
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: bovine (based on 100% sequence homology), mouse (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
• 技術: western blot: suitable
• NCBI登錄號: NP_055615
• UniProt登錄號: Q92556
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... ELMO1(9844)

说明

一般說明

Engulfment and cell motility protein 1 (ELMO1) is a cytoplasmic protein involved in the clearance of apoptotic cells by phagocytosis. ELMO1 is activated downstream of the phosphatidylserine receptor BAI1. ELMO1 binds to DOCK180 and facilitates its transport to the plasma membrane where DOCK180 activates the GTPase RAC1, possibly via Arf6. RAC1, like other small GTPases, mediate cytoskeleton remodeling and cell motility which is necessary for the internalization of target cells.

特異性

No homology to Rat was found.

This antibody recognizes ELMO1 at the ELMO domain.

免疫原

Epitope: ELMO domain

KLH-conjugated linear peptide corresponding to human ELMO1 at the ELMO domain.

應用

Detect ELMO1 using this Anti-ELMO1 Antibody validated for use in Western Blotting.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected ELMO1 on 10 µg of Jurkat cell lysate.

標靶描述

~78 kDa observed. This antibody exhibits strong affinity, high dilutions are recommended. The calculated molecular weight is 84 kDa, however ELMO1 has been shown as a ~78 kDa band in western blots (Gumienny, T.L., et al. (2001). Cell. 107:27–41.)

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Jurkat cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable