生物来源
rabbit
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性（根据同源性预测）
all
制造商/商品名称
Chemicon®
技术
ELISA: suitable
immunohistochemistry: suitable
运输
dry ice
基因信息
human ... NOS1(4842)
一般描述
The cellular production of highly reactive nitrogen species derived from nitric oxide, such as peroxynitrite, nitrogen dioxide and nitryl chloride, leads to the nitration of tyrosine resides in tissue proteins. The extent of protein nitrotyrosine formation provides an index of the production of reactive nitrogen species and potential cell damage over a period of time. Nitrotyrosine can be measured by amino-acid analysis of protein hydrolysates and detected, estimated semi-quantitatively and located in cells and tissues by immunocytochemical techniques using antibodies directed against the nitrotyrosine hapten.
特异性
NO2-Tyrosine
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
NO2-Tyrosine-G-BSA 1
NO-Tyr-G-BSA 1/233
Tyr-G-BSA 1/>100,000
NO2-5HT-G-BSA 1/>100,000
NO-5HT-G-BSA 1/>100,000
NO-Cys-G-BSA 1/>100,000
NO-W-G-BSA 1/>100,000
NO-His-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
NO2-Tyrosine-G-BSA 1
NO-Tyr-G-BSA 1/233
Tyr-G-BSA 1/>100,000
NO2-5HT-G-BSA 1/>100,000
NO-5HT-G-BSA 1/>100,000
NO-Cys-G-BSA 1/>100,000
NO-W-G-BSA 1/>100,000
NO-His-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
免疫原
NO2-Tyrosine-Glutaraldehyde-BSA
应用
Anti-Nitrotyrosine Antibody is an antibody against Nitrotyrosine for use in ELISA, IH.
Immunohistochemistry: 1:1,000-1:2,500
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Oxidative Stress
Oxidative Stress
外形
Rabbit antiserum. Liquid with 0.05% sodium azide.
储存及稳定性
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
S Y Yao et al.
Journal of neuroimmunology, 229(1-2), 146-156 (2010-08-21)
There are currently four known isoforms of nitric oxide synthase (NOS). Of these, neuronal NOS (nNOS) is known to be present exclusively in neurons, endothelial NOS (eNOS) in vascular endothelium, while the inducible form of NOS (iNOS) is known to
Maria A Pabón et al.
JCI insight, 3(18) (2018-09-21)
Chronic obstructive pulmonary disease (COPD), associated with cigarette smoke-induced (CS-induced) emphysema, contributes significantly to the global health care burden of disease. Although chronic kidney disease (CKD) may occur in patients with COPD, the relationship between COPD and CKD remains unclear.
Usua Laresgoiti et al.
Development (Cambridge, England), 143(20), 3686-3699 (2016-11-02)
Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first produce bronchiolar-fated and subsequently alveolar-fated progeny. The mechanisms controlling this bronchiolar-to-alveolar developmental transition remain largely unknown. We developed
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