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產品線
Novabiochem®
形狀
beads
反應適用性
reaction type: Fmoc solid-phase peptide synthesis
reactivity: amine reactive
製造商／商標名
Novabiochem®
應用
peptide synthesis
儲存溫度
2-30°C
一般說明
Novabiochem™′s 50-100 mesh REM resin [1] is an exceptionally high quality resin, designed specially for use in IRORI Kans and other parallel synthesis applications that require supports with reproducible substitution and swelling properties containing minimal leachable impurities. This material is derived from poly(chloromethylstyrene-styrene-divinylbenzene) manufactured to ISO 9001 standards. Unlike other Merrifield supports, which are prepared by chloromethylation of polystyrene, this matrix is prepared by co-polymerization of chloromethylstyrene, styrene and divinylbenzene. Since the amount of chloromethylstyrene added to the polymerization reaction can be precisely controlled, this leads to a highly defined resin with little batch to batch variation in functionality. The swelling characteristics of such resins are also more reproducible since the process of manufacture does not introduce additional cross-linking, as is the case with resins produced by chloromethylation. For applications of REM resin in SPOS see references [2-4].
Literature references
[1] A. Brown, et al. (1997) J. Am. Chem. Soc., 119, 3288.
[2] J. Cottney, et al. (1999) Bioorg. Med. Chem. Lett., 9, 1323.
[3] A. Born, et al. (2001) Bioorg. Med. Chem. Lett., 11, 2351.
[4] S. Caix-Haumesser, et al. (2001) Tetrahedron Lett., 42, 3721.
Literature references
[1] A. Brown, et al. (1997) J. Am. Chem. Soc., 119, 3288.
[2] J. Cottney, et al. (1999) Bioorg. Med. Chem. Lett., 9, 1323.
[3] A. Born, et al. (2001) Bioorg. Med. Chem. Lett., 11, 2351.
[4] S. Caix-Haumesser, et al. (2001) Tetrahedron Lett., 42, 3721.
聯結
Replaces: 01-64-0393
分析報告
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of chlorine after derivatization with 4-chloro-benzylamine): 0.80 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 50 - 100 mesh.
Appearance of substance (visual): beads
Loading (determined by elemental analysis of chlorine after derivatization with 4-chloro-benzylamine): 0.80 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 50 - 100 mesh.
法律資訊
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
TMAX is a trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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