8.52412

Fmoc-His(MBom)-OH

N-α-Fmoc-3-methoxybenzyloxymethyl-L-histidine Novabiochem^®

• 别名: Fmoc-His(MBom)-OH, N-α-Fmoc-N-π-(p-methoxybenzyloxymethyl)-L-histidine
• 经验公式（希尔记法）: C₃₀H₂₉N₃O₆
• 分子量: 527.57
• 分類程式碼代碼: 12352209

属性

• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: powder
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 官能基: Fmoc
• 儲存溫度: 15-25°C

说明

一般說明

A novel histidine derivative for Fmoc SPPS in which the π-imidazole nitrogen is blocked with the acid-labile MBom group, In contrast to Fmoc-His(Trt)-OH, coupling of this derivative is free from the risk of racemization, even under base-mediated coupling conditions. Methoxyamine should be added to the cleavage mixture to scavenge liberated formaldehyde.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] H. Hibino et al. (2011) Tetrahedron lett., 52, 4947.

分析報告

Colour (visual): white to off white
Appearance of substance (visual): powder
Purity (HPLC): ≥ 98.0 % (a/a)
Purity (DC(BAWO)): ≥ 98 %
Identity (IR): passes test
Solubility (1 mmole in 2 ml DMF): clear soluble
Enantiomeric purity: ≥ 99.5 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable