质量水平
表单
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
溶解性
water: soluble
运输
wet ice
储存温度
−70°C
一般描述
A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomer mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM.
A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomere mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM. Note: 150 nmol = 285 µg.
M.W. ~1900.
生化/生理作用
Cell permeable: yes
Primary Target
Telomerase activity in cell lysates
Telomerase activity in cell lysates
Product competes with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
序列
5′-d(TTAGGG)-3′
其他说明
Mata, J.E., et al. 1997. Toxicol. Appl. Pharmacol. 144, 189.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Manuel Bernabé-García et al.
Molecular oncology, 15(7), 1818-1834 (2021-03-14)
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere-independent functions of human TERT have been described. In this study, we report that TERT binds directly to the TCF binding elements located
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