559395
SB 203580, Hydrochloride
SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).
别名:
SB 203580, Hydrochloride, 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride
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所有图片(1)
About This Item
经验公式（希尔记法）:
C21H16FN3OS · xHCl
CAS号:
分子量:
377.43 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77
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品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
顏色
bright yellow
溶解度
water: 10 mg/mL
DMSO: soluble
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H
InChI 密鑰
WOSGGXINSLMASH-UHFFFAOYSA-N
一般說明
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
生化／生理作用
Cell permeable: yes
Primary Target
p38 MAP kinase
p38 MAP kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen
警告
Toxicity: Standard Handling (A)
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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