5.34347

hCNT2 Inhibitor

• 别名: hCNT2 Inhibitor, 8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
• 经验公式（希尔记法）: C₂₃H₂₄N₆O₄
• CAS号: 880155-70-4
• 分子量: 448.47
• UNSPSC代码: 12352200

属性

• 方案: ≥98% (HPLC)
• 质量水平: 100
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: pale yellow
• 溶解性: DMSO: 50 mg/mL
• 储存温度: 2-8°C

说明

一般描述

An aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na⁺-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC₅₀ of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

生化/生理作用

Primary Target
hCNT2

Reversible: yes

Target IC₅₀: 640 nM in COS-7 cells

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Tatani, K., et al. 2015. ACS Med. Chem. Lett.6, 244.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable