506600

Pamidronate, Disodium Salt

A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

• 别名: Pamidronate, Disodium Salt, 3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate
• 经验公式（希尔记法）: C₃H₉NO₇P₂ · 2Na · 5H₂O
• CAS号: 109552-15-0
• 分子量: 369.11
• MDL编号: MFCD01938386
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 描述: Merck USA index - 14, 7003
• 方案: ≥98% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic)
• 颜色: white
• 溶解性: water: 10 mg/mL
• 运输: ambient
• 储存温度: −20°C
• SMILES字符串: [Na+].[Na+].[P](=O)([O-])([O-])[C@@]([P](=O)([O-])O)(O)CC[N+H3].O.O.O.O.O
• InChI: 1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2
• InChI key: CZYWHNTUXNGDGR-UHFFFAOYSA-L

说明

一般描述

A calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget′s disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.

A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.

生化/生理作用

Cell permeable: no

Primary Target
Inhibitor of bone resorption

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重悬

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

其他说明

Fromigue, O., et al. 2000. J. Bone Miner. Res.15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs41, 289.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H302,H319
• 预防措施声明: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• 危险分类: Acute Tox. 4 Oral - Eye Irrit. 2
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable