5.06047

3,3′-Diamino-4′-methoxyflavone, DD1

• 别名: 3,3′-Diamino-4′-methoxyflavone, DD1, 3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1
• 经验公式（希尔记法）: C₁₆H₁₄N₂O₃
• 分子量: 282.29
• 分類程式碼代碼: 12352200

属性

• 化驗: ≥98% (HPLC)
• 品質等級: 200
• 形狀: powder
• 效力: 2 μM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 100 mg/mL
• 儲存溫度: 2-8°C

说明

一般說明

A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20 µM and 96 h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC₅₀ = 2.0 µM) and this effect is synergistic with bortezomib (Cat. No. 504314).

生化／生理作用

Cell permeable: yes

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Piedfer. M., et al, 2013. Biochim. Biophys. Acta.1833,1316
Quiney, C., et al, 2004. Leuk. Res.28, 851.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable