480458

NF-κB Activation Inhibitor X, Methysticin

• 别名: NF-κB Activation Inhibitor X, Methysticin, (6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6- dihydro-4-methoxy-2H-pyran-2-one
• 经验公式（希尔记法）: C₁₅H₁₄O₅
• CAS号: 495-85-2
• 分子量: 274.27
• MDL编号: MFCD21364778
• UNSPSC代码: 12352200

属性

• 方案: ≥99% (HPLC)
• 质量水平: 100
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze
• 颜色: white
• 溶解性: DMSO: 50 mg/mL
• 运输: wet ice
• 储存温度: −20°C
• InChI: 1S/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+
• InChI key: GTEXBOVBADJOQH-DUXPYHPUSA-N

说明

一般描述

Methysticin has been identified from kava to have potent NF-κB inhibitory activity and minimum toxicity. It is shown to inhibit NF-κB (IC₅₀ = 0.19 µg/ml) 100 times more potently than traditional kava in A549 cells in an in vitro luciferase-based assay. It is also reported to suppress the elevation of IKKα, p65, and COX-2 and the degradation of IκBα in A549 cultures stimulated with TNF-alpha; through Western Blot analysis.

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Shaik, A.A., et al. 2009. Bioorg Med Chem Lett.19, 5732.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable