474788

MG-132

≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem^®

• 别名: InSolution MG-132 in EtOH, ≥95% by HPLC, Proteasome Inhibitor XI
• 经验公式（希尔记法）: C₂₆H₄₁N₃O₅
• 分子量: 475.62
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• product name: MG-132 in EtOH, ≥95% by HPLC, InSolution, ≥95%, reversible proteasome inhibitor
• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 運輸包裝: ambient
• 儲存溫度: −70°C

说明

一般說明

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) is also available.

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.

生化／生理作用

Cell permeable: yes

K_i = 4 nM for proteasomal inhibition

Reversible: yes

Secondary Target
IKK

包裝

Packaged under inert gas

警告

Toxicity: Flammable (J)

外觀

A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.

重構

Following initital thaw, aliquot and freeze (-70°C).

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS02,GHS07
• 訊號詞: Danger
• 危險聲明: H225,H319
• 防範說明: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Flam. Liq. 2
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 53.6 °F - closed cup - Information refers to the main ingredient.
• 閃點（°C）: 12 °C - closed cup - Information refers to the main ingredient.