454862

MNK1/2 Inhibitor II, ETP-45835

The MNK1/2 Inhibitor II, ETP-45835 controls the biological activity of MNK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: MNK1/2 Inhibitor II, ETP-45835, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl, ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl
• 经验公式（希尔记法）: C₁₃H₁₆N₄ · 2HCl
• CAS号: 2136571-30-5
• 分子量: 301.21
• MDL號碼: MFCD27919983
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: water: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: C1(C2=CC=NC=C2)=CC(C3CCNCC3)=NN1

说明

一般說明

A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC₅₀ = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (≤15% inhibition at 5 µM). Reported to exhibit good aqueous solubility (>100 µM at pH 7.4) and inhibit the proliferation (IC₅₀ = 17 µM) and cellular eIF4E Ser²⁰⁹ phosphorylation (IC₅₀ = 4.7 µM) of MV4:11 cells.

A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC₅₀ = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against a panel of 24 other kinases (≤15% inhibition at 5 µM), including MNK upstream kinases B-Raf, ERK1, MEK1, and p38α. Reported to exhibit good aqueous solubility (>100 µM at pH 7.4) and inhibit the proliferation (IC₅₀ = 17 µM) and cellular eIF4E Ser²⁰⁹ phosphorylation (IC₅₀ = 4.7 µM) of acute myeloid leukemia MV4:11 cells.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Oyarzabal, J., et al. 2010. J. Med. Chem.53, 6618.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable