推荐产品
product name
前体mRNA剪接抑制剂，异银杏双黄酮, The Pre-mRNA Splicing Inhibitor, Isoginkgetin, also referenced under CAS 548-19-6, blocks the spliceosome-meidated splicing process.
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
yellow
溶解度
DMSO: 100 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C32H22O10/c1-39-18-6-3-15(4-7-18)26-14-24(38)31-22(36)12-21(35)29(32(31)42-26)19-9-16(5-8-25(19)40-2)27-13-23(37)30-20(34)10-17(33)11-28(30)41-27/h3-14,33-36H,1-2H3
InChI 密鑰
HUOOMAOYXQFIDQ-UHFFFAOYSA-N
一般說明
一种细胞可渗透的，天然分离的银杏双黄酮类化合物，通过在前剪接体/A复杂阶段阻断对剪接体介导的剪接过程，作为一般的前mRNA剪接抑制剂（在使用HeLa核提取物的剪接测定中，ICmax = 50 µM）。已显示异银杏素治疗以可逆的方式导致HEK293衍生的培养物中的生长停滞，而不会影响细胞活率（33 µM持续24 h）。
天然分离的银杏双黄酮类化合物，通过阻止前剪接体A复合物募集U4/U5/U6 tri-snRNP（稳定的核RNA及其相关蛋白）形成B复合物，作为剪接体介导的前mRNA剪接的细胞可渗透，可逆抑制剂（在使用HeLa核提取物的剪接测定中，IC50和ICmax分别为30和50 µM）。已显示异银杏素治疗以可逆的方式导致HEK293衍生的培养物中的生长停滞，而不会影响细胞活率（33 µM持续24 h）。
包裝
用惰性气体包装
警告
毒性：标准处理（A）
其他說明
Kim, H.Y., et al. 2008.Arch.Pharm. Res.31, 265.
O′Brien, K., et al. 2008.J. Biol. Chem.283, 33147.
Yoon, S,O., et al. 2006.Mol.Cancer Ther.5, 2666.
O′Brien, K., et al. 2008.J. Biol. Chem.283, 33147.
Yoon, S,O., et al. 2006.Mol.Cancer Ther.5, 2666.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Sang-Oh Yoon et al.
Molecular cancer therapeutics, 5(11), 2666-2675 (2006-11-24)
Matrix metalloproteinase (MMP)-9 plays a key role in tumor invasion. Inhibitors of MMP-9 were screened from Metasequoia glyptostroboides (Dawn redwood) and one potent inhibitor, isoginkgetin, a biflavonoid, was identified. Noncytotoxic levels of isoginkgetin decreased MMP-9 production profoundly, but up-regulated the
Wenbo Zhu et al.
ACS omega, 5(39), 25306-25311 (2020-10-13)
Deposition and dysfunction of U1 small nuclear ribonucleoprotein (snRNP) have been revealed in Alzheimer's disease (AD), but whether U1 is involved in the amyloid precursor protein (APP) and Tau pathways remains unclear. Here, we investigate this by inhibiting the U1
Kristine O'Brien et al.
The Journal of biological chemistry, 283(48), 33147-33154 (2008-10-02)
Membrane-permeable compounds that reversibly inhibit a particular step in gene expression are highly useful tools for cell biological and biochemical/structural studies. In comparison with other gene expression steps where multiple small molecule effectors are available, very few compounds have been
Hyun Pyo Kim et al.
Archives of pharmacal research, 31(3), 265-273 (2008-04-15)
Biflavonoids belong to a subclass of the plant flavonoid family. Distribution of biflavonoids in the plant kingdom is limited to several species. Previously, some pharmacological activities of biflavonoids were described such as inhibition of histamine release from mast cells and
Claudia Baumann et al.
Open biology, 13(11), 230133-230133 (2023-11-08)
In somatic cells, mitotic transcription of major satellite non-coding RNAs is tightly regulated and essential for heterochromatin formation and the maintenance of genome integrity. We recently demonstrated that major satellite transcripts are expressed, and chromatin-bound during mouse oocyte meiosis. Pericentric
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