341253

FAAH Inhibitor III, URB937

• 别名: FAAH Inhibitor III, URB937
• 经验公式（希尔记法）: C₂₀H₂₂N₂O₄
• 分子量: 354.40
• UNSPSC代码: 12352200

属性

• 方案: ≥95% (HPLC)
• 质量水平: 100
• 表单: powder
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: gray-white
• 溶解性: DMSO: 100 mg/mL
• 运输: ambient
• 储存温度: 2-8°C

说明

一般描述

A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC₅₀ = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC₅₀ >100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED₅₀ = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Clapper, J.R., et al. 2010. Nat. Neurosci.13, 1265.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable