推荐产品
product name
顺铂, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
yellow
溶解度
PBS with 140 mM NaCl: 1 mg/mL
water with 154 mM NaCl: 1 mg/mL
DMSO: 10 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/2Cl.2H3N.Pt/h;;2*1H3;
InChI 密鑰
JFUARQHXOQHNLK-UHFFFAOYSA-N
一般說明
具有强效抗肿瘤活性的铂配位复合物。
注：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。
注：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。
具有强效抗肿瘤活性的铂配位复合物。诱导癌细胞中的凋亡，可能通过caspase-3激活。据报道可使胶质瘤细胞对TNF-α-诱导的凋亡敏感。
注意：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。
注意：尽管顺铂在DMSO中高度可溶，但据报道由于配体被DMSO的亲核硫取代而变得无活性。建议在培养处理之前将氯化钠水溶液（154 mM NaCl，含或不含10 mg/mL甘露醇）或PBS（含140 mM NaCl）溶解。
生化／生理作用
主要靶标
诱导癌细胞凋亡
诱导癌细胞凋亡
产物不与ATP竞争。
可逆：否
细胞渗透性：否
警告
毒性：有毒 & 致癌/致畸性（G）
重構
溶液中不稳定；仅在使用前进行复溶。
其他說明
Hall, M.D., et al. 2014.Cancer Res. In press.
Duan, L., et al. 2001.J. Neurooncol.52, 23.
Mese, H., et al. 2000.Cancer Chemother.Pharmacol.46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv.Pharmacol.Chemother.16, 279.
Duan, L., et al. 2001.J. Neurooncol.52, 23.
Mese, H., et al. 2000.Cancer Chemother.Pharmacol.46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv.Pharmacol.Chemother.16, 279.
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險分類
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Jinan Li et al.
Frontiers in molecular neuroscience, 15, 835448-835448 (2022-03-01)
Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin. In zebrafish, the functional mechanotransduction channel is
Adib Behrouzi et al.
International journal of molecular sciences, 23(3) (2022-02-16)
Cisplatin can induce peripheral neuropathy, which is a common complication of anti-cancer treatment and negatively impacts cancer survivors during and after completion of treatment; therefore, the mechanisms by which cisplatin alters sensory neuronal function to elicit neuropathy are the subject
Laura Torresano et al.
Oncogenesis, 11(1), 24-24 (2022-05-10)
Lung cancer is the leading cause of cancer-related death worldwide despite the success of therapies targeting oncogenic drivers and immune-checkpoint inhibitors. Although metabolic enzymes offer additional targets for therapy, the precise metabolic proteome of lung adenocarcinomas is unknown, hampering its
Ali A Shati
Systems biology in reproductive medicine, 65(3), 236-249 (2018-12-07)
This study aimed to investigate the protective role of resveratrol (RES) against cisplatin (Cis)-induced testicular damage and reproductive dysfunction in rats and to examine the underlying mechanisms of protection including its effect on endoplasmic reticulum (ER) stress, P53, extracellular signal-regulated
Shruthi Sriramkumar et al.
Journal of translational medicine, 20(1), 246-246 (2022-06-02)
Platinum based agents-cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant disease that is uniformly fatal. Platinum treatment enriches for chemoresistant aldehyde
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