推荐产品
product name
半胱氨酸蛋白酶-8抑制物II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
品質等級
形狀
powder
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated
顏色
white to yellow
溶解度
DMSO: 10 mM
運輸包裝
ambient
儲存溫度
−20°C
一般說明
一种有效、细胞可渗透性且不可逆的caspase-8和颗粒酶B的抑制剂。有效抑制流行性感冒病毒诱导的HeLa细胞凋亡。还抑制颗粒酶B。当与纯化的天然或重组酶一起使用时，需要用酯酶进行预处理。也可使用5 mM（250 µg/76 µl）Z-IETD-FMK（目录号218840）的DMSO溶液。
一种有效、细胞可渗透性且不可逆的caspase-8（MACH，FLICE，Mch5）抑制剂。也抑制颗粒酶B。
生化／生理作用
主要靶标
caspase-8
caspase-8
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
警告
毒性：标准处理（A）
序列
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
重構
复溶后，等分并冷冻（-20°C）。储备溶液在-20°C下可稳定保存8个月。
分析報告
≥98%（HPLC）
其他說明
Takizawa, T., et al. 1999.Microbiol.Immunol.43, 245.
Martin, D.A., et al. 1998.J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998.FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281, 1312.
Martin, D.A., et al. 1998.J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998.FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281, 1312.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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