197228

BCRP Inhibitor IV, YHO-13351

The BCRP Inhibitor IV, YHO-13351 controls the biological activity of BCRP.

• 别名: BCRP Inhibitor IV, YHO-13351, Diethylaminoacetic acid, 1-(5-(( Z)-2-cyano-2-(3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate, Diethylaminoacetic acid, 1-(5-((Z)-2-cyano-2-(3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate
• 经验公式（希尔记法）: C₂₆H₃₃N₃O₄S · xCH₄O₃S
• 分子量: 483.62 (free base basis)
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥97% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic); protect from light
• 颜色: yellow
• 溶解性: water: 25 mg/mL
• 运输: wet ice
• 储存温度: −20°C
• SMILES字符串: O=C(CN(CC)CC)OC(CC1)CCN1C(S2)=CC=C2/C=C(C(C=C3)=CC(OC)=C3OC)\C#N.[xCH3SO3H]

说明

一般描述

An in vivo bioavailable (~87%; t_1/2<5 mins. during p.o. and i.v. administration) and highly water soluble (>100 mg/ml) diethylaminoacetate prodrug of YHO-13177 (Cat. No. 197227) that reverses BCRP-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200 mg/kg, i.p.).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Yamazaki, R., et al. 2011. Mol. Cancer Ther.10, 1252.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable