16-222
Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, FITC Conjugate
clone 3H10, Upstate®, from mouse
别名:
H3 histone, family 3A, H3S10P, Histone H3 (phospho S10), H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B)
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所有图片(2)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
mouse
品質等級
共軛
FITC conjugate
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
3H10, monoclonal
物種活性
human
製造商／商標名
Upstate®
技術
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
phosphorylation (pSer10)
基因資訊
human ... HIST1H3F(8968)
一般說明
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
特異性
Broad species cross-reactivity is expected.
Recognizes histone H3 phosphorylated at Ser10, MW 17 kDa.
免疫原
A proprietary immunogen based on a peptide sequence containing phospho-serine corresponding to residue 10 of human histone H3. Clone 3H10.
Epitope: Ser10
應用
Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, FITC Conjugate is a Mouse Monoclonal for detection of Histone H3 phosphorylated at serine 10. This mAb, also known as H3S10p,is labeled with Fluorescein isothiocyanate (FITC), published in peer reviewed journals & validated in WB, ICC & IF.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
Western Blot Analysis: 0.5-5 µg/mL of this lot detected phosphorylated histone H3 in acid extracted proteins from mitotic HeLa cells (Catalog # 17-306) treated with colcemid.
品質
Immunocytochemistry: Mitotic HeLa cells showed positive chromosome staining with 4μg/mL of this antibody.
標靶描述
17 kDa
外觀
Protein G Purified
Purified mouse monoclonal IgG in buffer containing PBS with 0.05% sodium azide, pH7.1.
儲存和穩定性
Stable for 1 year at from date of receipt.
分析報告
Control
Mitotic HeLa cells (IF).
Mitotic HeLa cells (IF).
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice.
Keqin Ren,Jing Lu,Aleksey Porollo,Chunying Du
The Journal of Biological Chemistry null
Antje M Wengner et al.
Molecular cancer therapeutics, 15(4), 583-592 (2016-02-03)
Monopolar spindle 1 (Mps1) has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of chromosomes to daughter cells. Here, we report the structure and functional characterization of two novel
Christopher Merritt et al.
Development (Cambridge, England), 137(11), 1787-1798 (2010-05-01)
FBF-1 and FBF-2 (collectively FBF) are two nearly identical Puf-domain RNA-binding proteins that regulate the switch from mitosis to meiosis in the C. elegans germline. In germline stem cells, FBF prevents premature meiotic entry by inhibiting the expression of meiotic
Agata Zieba et al.
Molecular & cellular proteomics : MCP, 11(7), M111-M111 (2012-03-24)
Fundamental open questions in signal transduction remain concerning the sequence and distribution of molecular signaling events among individual cells. In this work, we have characterized the intercellular variability of transforming growth factor β-induced Smad interactions, providing essential information about TGF-β
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