14-842-M

Lck Protein, activated, 10 µg

activated, N-terminal 6His-tagged, recombinant, human Lck full length, for use in Kinase Assays.

• UNSPSC代码: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

属性

• 生物来源: human
• 质量水平: 100
• 重组: expressed in baculovirus infected Sf21 cells
• 产品线: Upstate^®
• 比活: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• 分子量: M_w 59 kDa
• 纯化方式: (Ni²⁺/NTA-agarose)
• 种属反应性: human
• 制造商/商品名称: Upstate^®
• 技术: activity assay: suitable (kinase)
• 登记号: (FUNCTION: SwissProt: P06239 # Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyp); NM_005356.3
• NCBI登记号: NM_005356.3
• UniProt登记号: P06239
• 相关疾病: obesity; metabolic disorders

说明

一般描述

N-terminal 6His-tagged, recombinant, human Lck full length

应用

Auto-activated on column by incubating with Mg/ATP, excess ATP and MgAc removed by multiple column wash steps.

Research Category
Metabolism

Research Sub Category
Obesity

Metabolic Disorders

生化/生理作用

Protein Target: Lck

Target Sub-Family: TK

包装

Also available in 10 μg size and in bulk

Also available in 250 µg size or bulk --call for pricing and availability and reference catalog number 14-842M when ordering the 250 µg size.

目标描述

Lck

联系

Replaces: 14-710

外形

Ni²⁺/NTA-agarose

储存及稳定性

1 year at -70°C from date of shipment

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H317
• 预防措施声明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危险分类: Skin Sens. 1
• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°C): Not applicable