重組細胞
expressed in FreeStyle™ 293-F cells
品質等級
分子量
Mw ~66 kDa
製造商／商標名
Upstate®
技術
activity assay: suitable (histone methyltransferase (HMT))
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
基因資訊
human ... CARM1(10498)
一般說明
Product Source: Human
應用
Human recombinant CARM1 with an N-terminal FLAG tag expressed in FreeStyle 293-F cells.
Research Category
Nuclear Function
Nuclear Function
品質
routinely evaluated by methylation of histone H3
聯結
Replaces: 14-575
儲存和穩定性
6 months at -80°C.
其他說明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Varies by lot; see lot-specific datasheet for information on each lot.
法律資訊
FreeStyle is a trademark of Invitrogen Corp.
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Hongwei Li et al.
The Journal of biological chemistry, 277(47), 44623-44630 (2002-09-19)
The RNA-binding protein HuR stabilizes labile mRNAs carrying AU-rich instability elements. This mRNA stabilization can be induced by hypoxia, lipopolysaccharide, and UV light. The mechanism by which these stimuli activate HuR is unclear and might be related to post-translational modification
Melody D Fulton et al.
The Journal of biological chemistry, 297(4), 101123-101123 (2021-09-08)
Histone arginine methylation is a key post-translational modification that mediates epigenetic events that activate or repress gene transcription. Protein arginine methyltransferases (PRMTs) are the driving force for the process of arginine methylation, and the core histone proteins have been shown
Seth Frietze et al.
Cancer research, 68(1), 301-306 (2008-01-04)
Estrogen receptor alpha (ER alpha) mediates breast cancer proliferation through transcriptional mechanisms involving the recruitment of specific coregulator complexes to the promoters of cell cycle genes. The coactivator-associated arginine methyltransferase CARM1 is a positive regulator of ER alpha-mediated transcriptional activation.
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