119137

CGS 21680 hydrochloride

≥96% (HPLC), solid, adenosine A2A receptor agonist, Calbiochem^®

• 别名: 腺苷A2A受体激动剂I，CGS 21680，盐酸盐, CGS-21680，CGS21680，3-（4-（2-（（6-氨基-9-（（2R,3R,4S,5S）-5-（乙基氨甲酰基）-3,4-二羟基四氢呋喃-2-基）-9H-嘌呤-2-基）氨基）乙基）苯基）丙酸
• 经验公式（希尔记法）: C₂₃H₂₉N₇O₆ · xHCl
• CAS号: 124182-57-6
• 分子量: 499.52 (free base basis)
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• product name: 腺苷A2A受体激动剂I，CGS 21680，盐酸盐,
• 化驗: ≥96% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 100 mM
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22?/m0/s1
• InChI 密鑰: PAOANWZGLPPROA-OFRRTHGGSA-N

说明

一般說明

CGS 21680 is a potent adenosine A2A receptors agonist (Ki = 27 nM) and xanthin derivative. CGS 21680 HCl exhibits reduced affinity for A2B receptors (Ki = 67 nM), but offers greater selectivity over A1R (Ki = 290 nM) and A3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Been, shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease.

包裝

用惰性气体包装

警告

毒性：标准处理（A）

外觀

以盐酸盐形式提供。

重構

在复溶后，分装并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

The molecular weight of CGS 21680 Hydrochloride this compound is batch-specific due to variable water content. For batch-specific molecular weight information, please refer the vial label or the certificate of analysis. The provided molecular weight represents the baseline molecular weight without water.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable