116815-M

Adenosine 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt

A cell-permeable cAMP analog that binds cAMP-receptor proteins.

• 别名: Adenosine 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt, Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
• 经验公式（希尔记法）: C₁₀H₁₁N₅O₅PS · 4C₆H₁₆N
• CAS号: 71774-13-5
• 分子量: 753.06
• UNSPSC代码: 12352200

属性

• 方案: ≥98% (HPLC)
• 表单: crystalline solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic)
• 溶解性: water: 20 mg/mL
• 储存温度: −20°C

说明

一般描述

A cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg. λ_max = 258 nm; ε_max = 15,000 M^-1cm-1 (pH 7..0).

Note: 10 µmol = 4.47 mg.

生化/生理作用

Primary Target
cAMP-receptor proteins

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.

其他说明

Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun.182, 1356.
Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch.420, 336.
Takuma, T., and Ichida, T. 1991. J. Biochem.110, 292.
Dostmann, W.R., et al. 1990. J. Biol. Chem.265, 10484.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable