09-466

Anti-phospho-CrkL (Tyr207) Antibody

Upstate^®, from rabbit

• UNSPSC代码: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 抗体形式: affinity purified immunoglobulin
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 纯化方式: affinity chromatography
• 种属反应性: mouse, rat, human
• 制造商/商品名称: Upstate^®
• 技术: western blot: suitable
• NCBI登记号: NP_005198
• UniProt登记号: P46109
• 运输: dry ice
• 靶向翻译后修饰: phosphorylation (pTyr207)
• 基因信息: human ... CRKL(1399)

说明

一般描述

CRKL belongs to a family of adaptor proteins containing SH2/SH3 domains that couple to effector proteins including p130CAS, SOS, Abl, and Arg. CRKL plays a role in the mediation of Integrin- and Rac-dependent cell migration and in Ras-dependent activation of JNK. The protein is also involved in T-cell activation. Phosphorylation of CrkL on Tyr207 is known to be correlated with its inhibition.

特异性

Recognizes CrkL only when phosphorylated on Tyr207.

免疫原

KLH synthetic peptide including and encompassing Tyr 207 of human CrkL.

应用

Detect phospho-CrkL (Tyr207) using this Anti-phospho-CrkL (Tyr207) Antibody validated for use in WB.

Research Category
Signaling

Research Sub Category
Cytoskeletal Signaling

质量

Routinely evaluated by western blot on K563 cell lysates.

目标描述

39 kDa

外形

Purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
K562

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 2