推荐产品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
human
製造商／商標名
Upstate®
技術
ChIP: suitable (ChIP-seq)
dot blot: suitable
inhibition assay: suitable (peptide)
multiplexing: suitable
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
acetylation (Lys 4)
基因資訊
human ... H3F3B(3021)
特異性
组蛋白H3在Lys4上乙酰化时
预计具有广泛的物种交叉反应性
免疫原
KLH偶联合成肽包含序列 ...RT[AcK]Q...，其中[AcK]对应于人组蛋白H3的乙酰赖氨酸4
應用
建议的稀释度：
蛋白质印迹：1:1000 - 1:10,000
蛋白质印迹：1:1000 - 1:10,000
抗乙酰基组蛋白H3（Lys 4）抗体是一种兔多克隆抗体，用于检测乙酰基组蛋白H3（Lys 4），也称为H3K4Ac，组蛋白H3（乙酰基K4）& 已在Mplex、WB、PIA、ChIP、ChIP-seq、DB中得到验证。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
品質
已通过免疫印迹进行常规评估。
標靶描述
Mr ~17kDa
外觀
100 μL免疫亲和纯化的兔IgG，溶于在含有0.1 M Tris-甘氨酸（pH 7.4）和0.15 M NaCl，并含有0.05%叠氮化钠和30%甘油的缓冲液中
免疫亲和纯化
儲存和穩定性
自运送之日起在-20°C下保存1年
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Runsheng He et al.
Nucleic acids research, 45(11), 6427-6441 (2017-04-13)
Epigenetic regulation of chromatin plays a critical role in controlling embryonic stem (ES) cell self-renewal and pluripotency. However, the roles of histone demethylases and activating histone modifications such as trimethylated histone 3 lysine 4 (H3K4me3) in transcriptional events such as
Federico Forneris et al.
The Journal of biological chemistry, 281(46), 35289-35295 (2006-09-22)
Human lysine-specific demethylase (LSD1) is a chromatin-modifying enzyme that specifically removes methyl groups from mono- and dimethylated Lys4 of histone H3 (H3-K4). We used a combination of in vivo and in vitro experiments to characterize the substrate specificity and recognition
Cheng-Yu Yang et al.
Oncotarget, 8(20), 33756-33769 (2017-04-20)
Aberrant activation of histone lysine-specific demethylase (LSD1) increases tumorigenicity; hence, LSD1 is considered a therapeutic target for various human cancers. Although melatonin, an endogenously produced molecule, may defend against various cancers, the precise mechanism involved in its anti-oral cancer effect
Fenfen Li et al.
The Journal of biological chemistry, 291(9), 4523-4536 (2016-01-07)
Inhibiting class I histone deacetylases (HDACs) increases energy expenditure, reduces adiposity, and improves insulin sensitivity in obese mice. However, the precise mechanism is poorly understood. Here, we demonstrate that HDAC1 is a negative regulator of the brown adipocyte thermogenic program.
Hainan Zhao et al.
Plant physiology, 176(4), 2789-2803 (2018-02-22)
Genomic regions free of nucleosomes, which are hypersensitive to DNase I digestion, are known as DNase I hypersensitive sites (DHSs) and frequently contain cis-regulatory DNA elements. To investigate their prevalence and characteristics in maize (Zea mays), we developed high-resolution genome-wide
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