05-644
抗-CAR抗体，克隆RmcB
clone RmcB, Upstate®, from mouse
别名:
46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3 binding protein, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, coxsackie virus B receptor, coxsackie virus and adenovirus receptor
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所有图片(4)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
RmcB, monoclonal
物種活性
human, rat, mouse
製造商／商標名
Upstate®
技術
immunocytochemistry: suitable
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... CXADR(1525)
一般說明
柯萨奇病毒和腺病毒受体（CAR）介导柯萨奇B病毒和许多腺病毒的细胞附着和感染。CAR还介导同型细胞间相互作用。在极化的上皮细胞中，CAR与紧密连接紧密相关，在紧密连接中，CAR有助于溶质和大分子的细胞旁流动。CAR′s的生物学作用尚不明确，但新出现的证据表明它可能在胚胎发育和调节细胞增殖中起作用。
特異性
识别分子量约为6 kDa的CAR。
免疫原
天然人柯萨奇病毒-腺病毒受体蛋白。
應用
免疫细胞化学：
1-2 μg/mL先前批次在HeLa细胞，hCAR转染的CHO细胞中显示出CAR的阳性免疫染色，但在用4%多聚甲醛固定并用0.2%Triton-X透化的未转染的CHO细胞中则没有。
1-2 μg/mL先前批次在HeLa细胞，hCAR转染的CHO细胞中显示出CAR的阳性免疫染色，但在用4%多聚甲醛固定并用0.2%Triton-X透化的未转染的CHO细胞中则没有。
抗CAR抗体，克隆RmcB可检测CAR的水平 & 已出版 & 并经过验证可用于IC & WB。
品質
已通过蛋白质印迹对小鼠小肠裂解液进行了评估。
蛋白质印迹分析：
该抗体的1：500的稀释液在10 µg小鼠小肠裂解液中检测到Car。
蛋白质印迹分析：
该抗体的1：500的稀释液在10 µg小鼠小肠裂解液中检测到Car。
標靶描述
~46 kDa
外觀
形式：纯化
纯化的小鼠单克隆IgG1，溶于含有0.1M Tris甘氨酸（pH 7.4）、0.15M NaCl、0.05％叠氮化钠的缓冲液中。
其他說明
浓度：请参考批次特异性浓缩物的分析证书。
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Jeffrey E Teigler et al.
Journal of virology, 86(18), 9590-9598 (2012-07-13)
Adenovirus (Ad) vaccine vectors have proven highly immunogenic in multiple experimental models, but the innate immune responses induced by these vectors remain poorly characterized. Here we report innate cytokine responses to 5 different Ad vectors in 26 rhesus monkeys. Vaccination
Sarah L Hulin-Curtis et al.
Oncotarget, 9(41), 26328-26341 (2018-06-15)
Ovarian cancer is often termed a silent killer due to the late onset of symptoms. Whilst patients initially respond to chemotherapy, they rapidly develop chemo-resistance. Oncolytic adenoviruses (OAds) are promising anti-cancer agents engineered to "hijack" the unique molecular machinery of
Antitumor effects of bladder cancer-specific adenovirus carrying E1A-androgen receptor in bladder cancer.
Zhai, Z; Wang, Z; Fu, S; Lu, J; Wang, F; Li, R; Zhang, H; Li, S; Hou, Z; Wang, H; Rodriguez, R
Gene Therapy null
Y Watanabe et al.
Cancer gene therapy, 19(11), 767-772 (2012-09-08)
Replication-selective oncolytic viruses are being developed for human cancer therapy. We previously developed an attenuated adenovirus (OBP-301, Telomelysin), in which the human telomerase reverse transcriptase promoter element drives expression of E1A and E1B genes linked with an internal ribosome entry
Xiaowei Zhang et al.
Journal of virology, 87(22), 12407-12421 (2013-09-13)
Enteroviruses can frequently target the human central nervous system to induce a variety of neurological diseases. Although enteroviruses are highly cytolytic, emerging evidence has shown that these viruses can establish persistent infections both in vivo and in vitro. Here, we
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