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Merck
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文件

04-1470

Sigma-Aldrich

Anti-OX40L (CD252) Antibody, clone RM134L

clone RM134L, from rat

别名:

Tumor necrosis factor ligand superfamily member 4, OX40 ligand, OX40L, CD252

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rat

品質等級

100

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

RM134L, monoclonal

物種活性

mouse

技術

flow cytometry: suitable
immunohistochemistry: suitable

同型

IgG2bκ

NCBI登錄號

NP_033478

UniProt登錄號

P43488

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

mouse ... Tnfsf4(22164)

相关类别

一般說明

OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.

特異性

This antibody recognizes the extracellular domain of OX40L.

免疫原

Mouse OX40L cDNA-transfected NRK cells

應用

Anti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)

品質

Evaluated by Flow Cytometry in mouse OX40L/L5178Y cells.

Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.

標靶描述

22 kDa calculated

外觀

Format: Purified

分析報告

Control
Mouse OX40L/L5178Y cells

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Akihiko Hoshino et al.
European journal of immunology, 33(4), 861-869 (2003-04-03)
Bronchial asthma is characterized by massive infiltration of eosinophils and airway hyperreactivity (AHR), which are caused by overproduction of Th2 cytokines (IL-4, IL-5, and IL-13) by allergen-specific T cells. We recently demonstrated a critical contribution of OX40 ligand (OX40L) to

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