推荐产品
等級
certified reference material
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
drug control
Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
濃度
1.0 mg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
clinical testing
格式
single component solution
儲存溫度
2-8°C
SMILES 字串
O=C1CN=C(C2=CC=CC=C2F)C3=CC(Cl)=CC=C3N1CCN(CC)CC
InChI
1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H
InChI 密鑰
ZIIJJOPLRSCQNX-UHFFFAOYSA-N
一般說明
Flurazepam is a benzodiazepine, sold under the trade names Dalmane and Salmadorm for treament of mild to moderate insomnia. This analytical reference standard is suitable for many LC/MS or GC/MS applications from urine drug testing and clinical toxicology to forensic toxicology analysis.
應用
- Flurazepam in Sleep Research: Flurazepam, a benzodiazepine receptor agonist, is used in sleep epidemiology to explore its effects on sleep patterns and quality. This sedative-hypnotic is evaluated for its potential to improve sleep among various populations, contributing valuable insights into sleep medicine (Fernandez-Mendoza et al., 2024).
- Pharmacology and GABA Receptors: Studies involving Flurazepam help elucidate its mechanism as a GABAergic compound, particularly in the context of its interaction with GABA(A) receptors. This research is foundational in neuropharmacology, providing deeper understanding of how benzodiazepines modulate neuronal activity and contribute to their therapeutic and side effects (Sun et al., 2023).
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes,Central nervous system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
Damien E Earl et al.
Neural plasticity, 2012, 405926-405926 (2012-07-26)
Cessation of one-week oral administration of the benzodiazepine flurazepam (FZP) to rats results in withdrawal anxiety after 1 day of withdrawal. FZP withdrawal is correlated with synaptic incorporation of homomeric GluA1-containing α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) in the proximal stratum radiatum
Michal Abrahamowicz et al.
Statistics in medicine, 31(11-12), 1014-1030 (2011-11-19)
Pharmacoepidemiology investigates associations between time-varying medication use/dose and risk of adverse events. Applied research typically relies on a priori chosen simple conventional models, such as current dose or any use in the past 3 months. However, different models imply different risk
Susan M Hanson et al.
British journal of pharmacology, 162(3), 673-687 (2010-10-15)
Although the functional effects of benzodiazepines (BZDs) on GABA(A) receptors have been well characterized, the structural mechanism by which these modulators alter activation of the receptor by GABA is still undefined. We used disulphide trapping between engineered cysteines to probe
Jessica A Burket et al.
Epilepsy & behavior : E&B, 16(3), 415-417 (2009-09-19)
The inbred Balb/c mouse strain was more sensitive than the outbred NIH Swiss mouse to flurazepam's ability to antagonize electrically precipitated seizures. In prior work, a reduction in flurazepam's antiseizure efficacy was not observed 24h after forcing Balb/c mice to
Cristian Palmiere et al.
Forensic science international, 188(1-3), e17-e19 (2009-05-05)
A case of sustained combustion of a human body that occurred in 2006 in Geneva, Switzerland, is presented. The body of a man was discovered at home and found to have been almost completely incinerated between the knees and the
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