810601P

16:0-5 Doxyl PC

Avanti Research^™ - A Croda Brand 810601P, powder

• 别名: 1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine
• 经验公式（希尔记法）: C₄₆H₉₀N₂O₁₀P
• CAS号: 188004-24-2
• 分子量: 862.19
• 分類程式碼代碼: 41141825
• NACRES: NA.25

属性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 1 mg (810601P-1mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand 810601P
• 脂質類型: ESR probes; phospholipids
• 運輸包裝: dry ice
• 儲存溫度: −20°C

说明

一般說明

Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.

Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes. The excretory and secretory products of helminths has a small hapten-like portion called phosphorylcholine (PC). The 5^th carbon of the sn-2 stearic acid chain of 1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine analog has a Doxyl PC, a spin probe attached to it covalently.

應用

16:0-5 Doxyl PC may be used:

• as a component in virus-like large unilamellar vesicles (VL LUVs) to quench 4-chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD) fluorescence emission
• in the preparation of multi-lamellar vesicles (MLVs) as a site-specific quencher to perform fluorescence quenching studies
• in the preparation of spin-labelled multi-lamellar vesicles (MLVs)

生化／生理作用

Phosphatidylcholine (PC) lowers the levels of cholesterol and triglycerides.

包裝

5 mL Clear Glass Sealed Ampule (810601P-1mg)

準備報告

Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全信息

• 儲存類別代碼: 11 - Combustible Solids