方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 50 μg (810230P-50ug)
制造商/商品名称
Avanti Research™ - A Croda Brand 810230P
运输
dry ice
储存温度
−20°C
一般描述
Safingol belongs to the lysosphingolipid class and is the synthetic L-threo-stereoisomer of (D-erythro-) sphinganine.
生化/生理作用
Safingol, a competitive inhibitor of sphingosine kinase 1, exhibits anticancer activity. It is known to increase antitumor activity of cisplatin in xenograft experiments.
包装
5 mL Amber Glass Screw Cap Vial (810230P-50ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Synthesis of threo-beta-aminoalcohols from aminoaldehydes via chelation-controlled additions. Total synthesis of l-threo sphingosine and safingol
Jung ME and Yi SW
Tetrahedron Letters, 53(32), 4216-4220 (2012)
Mark A Dickson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(8), 2484-2492 (2011-01-25)
Sphingosine 1-phosphate (S1P) is an important mediator of cancer cell growth and proliferation. Production of S1P is catalyzed by sphingosine kinase 1 (SphK). Safingol, (l-threo-dihydrosphingosine) is a putative inhibitor of SphK. We conducted a phase I trial of safingol (S)
Jesse Coward et al.
Autophagy, 5(2), 184-193 (2008-12-23)
Safingol, the synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine, is an inhibitor of protein kinase C and sphingosine kinase in vitro, and in some cell types has been implicated in ceramide generation and induction of apoptosis. Utilizing electron microscopy, acridine orange
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