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化驗
>99% (TLC)
形狀
liquid
包裝
pkg of 1 × 1 mL (810207X-100ug)
pkg of 1 × 1 mL (810207X-50ug)
製造商／商標名
Avanti Research™ - A Croda Brand 810207X
濃度
0.05 mg/mL (810207X-50ug)
0.1 mg/mL (810207X-100ug)
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
Sphingosine-1-phosphate is a phosphorylated sphingosine analog and is polar. It is terminally labelled by fluorescent nitrobenzo-2-oxa-1,3-diazole (NBD) group. Sphingosine-1-phosphate is abundantly stored in platelets.
應用
NBD sphingosine-1-phosphate has been used as a substrate in the detection of sphingosine-1-phosphate phosphatases (SPPase) enzymatic activity by in vitro assay.
生化／生理作用
Sphingosine-1-phosphate (S1P) initiates DNA synthesis. It is also involved in cell division, cell growth and platelet activation. S1P mediates cell movement, differentiation and survival. It specifically stimulates endothelial cells.
包裝
5 mL Amber Glass Screw Cap Vial (810207X-100ug)
5 mL Amber Glass Screw Cap Vial (810207X-50ug)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3
標靶器官
Central nervous system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 3
Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
Ito K, et al.
Biochemical and biophysical research communications, 357(1), 212-217 (2007)
Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior
Hakogi T, et al.
Bioorganic & Medicinal Chemistry Letters, 13(4), 661-664 (2003)
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.
Serra M and Saba JD
Advances in Enzyme Regulation, 50(1), 349-362 (2010)
Sphingosine-1-phosphate phosphatase 2 regulates pancreatic islet beta-cell endoplasmic reticulum stress and proliferation
Taguchi Y, et al.
The Journal of Biological Chemistry, 291(23), 12029-12038 (2016)
Gaelen S Smith et al.
Biomolecules, 3(3), 351-368 (2014-03-13)
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupled-receptors (GPCRs) implicated in mammalian development, angiogenesis, immunity and tissue regeneration. S1P functions as a trophic factor for many cell types, including embryonic stem cells (ESCs). Sphingosine
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