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描述
25-hydroxycholesterol-3-sulfate (sodium salt)
化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 10 mg (700017P-10mg)
pkg of 1 × 5 mg (700017P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@@]12[C@]([C@](CC[C@H](OS(=O)([O-])=O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)(O)C.[Na+]
一般說明
3-硫酸-25-羟化胆固醇(25-hydroxycholesterol-3-sulfate, 25OHC3S)是一种核氧化固醇。在类固醇急性调节蛋白(STARD1)过表达后，该氧化类固醇在肝细胞核内大量蓄积。
應用
3-硫酸-25-羟化胆固醇已用于诱导抗炎反应，并用于研究其对淋巴细胞迁移的影响。还可作为氧化固醇硫酸酯的标准品，用于质谱和液相色谱分析。
生化／生理作用
3-硫酸-25-羟胆固醇(25OHC3S)参与肝脏中的脂质稳态平衡，也是脂质代谢的调节因子。25OHC3S作用于肝X受体(LXR)和固醇调节元件结合蛋白(SREBP)，通过下调肝细胞和巨噬细胞中生物合成通路的酶，抑制胆固醇合成。还可作为激动剂作用于过氧化物酶体增殖物激活受体γ(PPAR-γ)，并调节基于核因子κ-轻链增强子(NF-κB)的炎症反应。25OHC3S可调节肝细胞中肿瘤坏死因子α(TNFα)诱发的炎症反应。
包裝
5 mL琥珀色玻璃螺旋盖样品瓶(700017P-10mg)
5 mL琥珀色玻璃螺旋盖样品瓶(700017P-5mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Leyuan Xu et al.
American journal of physiology. Endocrinology and metabolism, 302(7), E788-E799 (2012-01-26)
The nuclear receptor peroxisome proliferator-activated receptors (PPARs) are important in regulating lipid metabolism and inflammatory responses in macrophages. Activation of PPARγ represses key inflammatory response gene expressions. Recently, we identified a new cholesterol metabolite, 25-hydroxycholesterol-3-sulfate (25HC3S), as a potent regulatory
Yongjie Ma et al.
American journal of physiology. Endocrinology and metabolism, 295(6), E1369-E1379 (2008-10-16)
The oxysterol receptor LXR is a key transcriptional regulator of lipid metabolism. LXR increases expression of SREBP-1, which in turn regulates at least 32 genes involved in lipid synthesis and transport. We recently identified 25-hydroxycholesterol-3-sulfate (25HC3S) as an important regulatory
Shunlin Ren et al.
Biochemical and biophysical research communications, 360(4), 802-808 (2007-07-13)
Recently, a novel oxysterol, 5-cholesten-3beta, 25-diol 3-sulfate (25HC3S) was identified in primary rat hepatocytes following overexpression of the cholesterol transport protein, StarD1. This oxysterol was also detected in human liver nuclei. In the present study, 25HC3S was chemically synthesized. Addition
Leyuan Xu et al.
Lipids, 45(9), 821-832 (2010-08-12)
Dysregulation of lipid metabolism is frequently associated with inflammatory conditions. The mechanism of this association is still not clearly defined. Recently, we identified a nuclear oxysterol, 25-hydroxycholesterol-3-sulfate (25HC3S), as an important regulatory molecule involved in lipid metabolism in hepatocytes. The
Tetsuya Sakurai et al.
Science signaling, 11(541) (2018-08-02)
Although immune responses are essential to protect the body from infection, they can also harm tissues. Certain tissues and organs, including the eye, constitute specialized microenvironments that locally inhibit immune reactivity. Dedicator of cytokinesis protein 2 (DOCK2) is a Rac-specific
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